Oso is one of those neighborhood treasures that makes you feel like you’ve discovered something truly special in Harlem. This intimate Mexican spot strikes the perfect balance between authentic flavors and creative interpretations that keep locals coming back and downtown folks making the uptown trek.

What makes Oso truly shine is chef Cassandra’s approach to regional Mexican cuisine—her handmade tortillas are the foundation for some seriously memorable tacos. The short rib version with pickled onions and habanero salsa has developed something of a cult following, and rightfully so. The seafood dishes show equal finesse, particularly the aguachile with whatever fish is freshest that day.

The vibe here perfectly captures what makes uptown dining so appealing—it’s sophisticated without being stuffy, vibrant without being overwhelming. The small bar turns out exceptional mezcal cocktails that complement the food beautifully, with bartenders who are genuinely passionate about helping you find your perfect match.

What’s perhaps most compelling about Oso is how it serves as a neighborhood gathering spot while simultaneously elevating the dining scene. You’ll find families celebrating special occasions alongside couples on date night and friends catching up over shared plates.

In a city where restaurants often feel either too casual or too precious, Oso strikes that perfect sweet spot that makes you want to return again and again.